|
KMID : 0616120220530020079
|
|
Korean Journal of Pharmacognosy
2022 Volume.53 No. 2 p.79 ~ p.86
|
|
|
Neuroprotective Activity of Boesenbergia rotunda Against Glutamate Induced Oxidative Stress in HT22 Cells
|
|
Kim Eun-Seo
Ma Choong-Je
|
|
|
Abstract
|
|
|
|
Excessive glutamate causes oxidative stress in neuronal cells, which can cause degenerative neurological disorders. We tried to find medicinal plant showed neuroprotective activity by using glutamate-injured HT22 cell as a model system. In this study, we found that Boesenbergia rotunda methanol extract showed neuroprotective activity against glutamate induced neurotoxicity in mouse hippocampal HT22 cells. B. rotunda methanol extract suppressed the formation of reactive oxygen species and decreased intracellular Ca2+concentration. Also, B. rotunda made mitochondrial membrane potential maintain to normal levels. In addition, B. rotunda increased total glutathione amount and activated antioxidative enzyme such as glutathione reductase and glutathione peroxidase compared to glutamate-treated groups. These results suggested that B. rotunda decreased neuronal cell death damaged by high concentrations of glutamate treatment, via antioxidative mechanism and might be one of candidate of development of new drug to treat neurodegenerative disease such as Alzheimer’s disease.
|
|
|
KEYWORD
|
|
|
Boesenbergia rotunda, Alzheimer’s disease, Neuroprotection, Oxidative stress, HT22 cells
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|